RNA Details
Disease Name
cataract
Tissue
eye
RNA Symbol
miR-22-3p
RNA ID
RNA Type
miRNA
Alteration Pattern
a tubulin acetylation
Species
homo sapiens
Detection Methods
immunofluorescence; q-PCR; etc.
Target
HDAC 6
Pathway
NA
PubMed ID
Title
MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of alfa-tubulin acetylation
Year
2020
Function
These findings suggest that mir-22-3p prevents lens fibrotic progression by targeting hdac6 thereby promoting alfa-tubulin acetylation. The 'mir-22-hdac6-alfa-tubulin (de)acetylation' signalling axis may be therapeutic targets for the treatment of fibrotic cataract.